gastric corpus atrophy in gastric cancer screenings: benefits and drawbacks

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dariush nasrollahzadeh

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Gastric corpus atrophy in gastric cancer screenings: Benefits and drawbacks

* Corresponding Author: Dariush Nasrollahzadeh, M.D Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden Telefax:+46 852482369 Email: [email protected] Recieved: 1 Jul. 2011 Accepted: 30 Jul. 2011 Gastric cancer (GC) is one the major health burden in the world. In Iran GC is the most common malignancy among men and second to breast cancer among women...

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The saga of gastric corpus atrophy.

The loss of gastric oxyntic glands (corpus atrophy) is emerging as a marker of gastric cancer risk as indicated by low Pepsinogen I (PGI) levels 1 2. There is a need to take into account the natural history and temporal dynamics of such an entity in order to better understand its significance and especially its implications for cancer prevention and screening. Atrophy of the gastric corpus was ...

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Serological assessment of gastric mucosal atrophy in gastric cancer

BACKGROUND Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers the possibility to detect preneoplastic gastric mucosal conditions. Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia. METHODS Histologica...

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Rapid quantitative assessment of gastric corpus atrophy in tissue sections.

BACKGROUND/AIMS Grading of Helicobacter pylori induced atrophic gastritis using the updated Sydney system is severely limited by high interobserver variability. The aim of this study was to set up a quantitative test of gastric corpus mucosal atrophy in tissue sections and test its reproducibility and correlation with the Sydney scores of atrophy. METHOD Mucosal atrophy was assessed in 124 ha...

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Helicobacter pylori and gastric atrophy--cancer paradoxes.

It has long been recognized that chronic gastritis is a precursor of gastric cancer only when atrophy is part of the spectrum of lesions (/). These observations are paradoxical, since atrophy is characterized by the loss of glandular epithelium, whereas cancer represents its excessive and anarchic replication. The phenomena that give rise to atrophy in the chronic gastritis complex are presentl...

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Gastric atrophy in childhood.

Chronic gastritis and gastric atrophy are common in later adult life. Hebbel (1943) investigated the incidence of chronic gastritis at necropsy in patients dying from a variety of causes but whose history revealed no evidence of gastric symptoms. He found that gastric changes of any degree were rare below the age of 30 years and severe changes uncommon below the age of 50 years. Atrophic gastri...

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عنوان ژورنال:
middle east journal of digestive diseases

جلد ۳، شماره ۲، صفحات ۸۹-۰

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